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2018 04/04

Genetic analysis of Wnt/PCP genes in neural tube defects.

Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH*, Zhang T*, Wang H*
BMC Med Genomics. 2018 Apr 4; 11(1): 38. doi: 10.1186/s12920-018-0355-9.
2018 03/28

Decreased activity of RCAN1.4 is a potential risk factor for congenital heart disease in a Han Chinese population.

Cheng LP, Li PQ, Wang H, Yang XY, Zhou HM, Tao W*, Tian J*, Wang H*
Protein & Cell. 2018 Mar 28. doi: 10.1007/s13238-018-0525-8.
2018 01/09

Sensing and transmitting intracellular amino acid signals through reversible lysine aminoacylations.

He XD, Gong W, Zhang JN, Nie J, Yao CF, Guo FS, Lin Y, Wu XH, Li F, Li J, Sun WC, Wang ED, An YP, Tang HR, Yan GQ, Yang PY, Wei Y, Mao YZ, Lin PC, Zhao JY, Xu YH*, Xu W*, Zhao SM*
Cell metabolism. 2018 Jan 9;27(1),151-166. doi: 10.1016/j.cmet.2017.10.015.
2018 01/01

Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.

Wang HR, Zhang C, Wang XW, Lian YR, Guo B, Han M, Zhang XE, Zhu XT, Xu SX, Guo ZL, Bi YL, Shen Q, Wang X, Liu JJ, Zhuang Y, Ni T, Xu H*, Wu X*
Int J Biol Sci. 2018 Jan 1; 14(1): 10-20. doi: 10.7150/ijbs.22768.
2017 11/10

Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation.

Lei Y., Liu L., Zhang S., Shicheng Guo S., Li X., Wang J., Bo Su B., Fang Y., Chen X, Ke H. and W. Tao*
Molecular Cancer. 2017 Nov 10;16:170. DOI 10.1186/s12943-017-0736-2.
2017 09/29

Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects.

Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*
Birth Defects Res A. 2017 Sep 29. doi: 10.1002/bdr2.1122.
2017 09/19

Mst-1 deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux.

Zhang M., Tao W., Yuan Z. and Y. Liu
J. Neurochem. 2017 Sep 19;2143(2):244-256.
2017 06/19

A missense mutation in TCN2 is associated with decreased risk for congenital heart defects and may increase cellular uptake of vitamin B12 via Megalin.

Li P, Huang L, Zheng Y, Pan X, Peng R, Jiang Y, Finnell RH, Li H, Qiao B, Wang HY*
Oncotarget. 2017 July 19;8(33):55216-55229. doi: 10.18632/oncotarget.19377.
2017 06/11

DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation.

Jin Y, Chen YH, Zhao SM, Guan KL, Zhuang Y, Zhou WH, Wu X*, Xu T*
PNAS. 2017 Jul 11;114(28):7408-7413.
2017 06/06

Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

Zhu X, Xie S, Xu T, Wu X*, Han M
Mol Metab. 2017 Jun; 6: 494-502.
2017 04/17

Large is required for normal astrocyte migration and retinal vasculature development.

Zhou M, Wang H, Ren H, Jiang R, Zhang C, Wu X*, Xu G*
Cell Biosci. 2017 Apr 17;7:18.
2017 04/15

L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration.

Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL
Mol Cell Biol. 2017 Apr 15;37(8):e00492-16.
2017 04/04

The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice.

Li G, Ye ZS, Shi C, Sun L, Han M, Zhuang Y, Xu T, Zhao SM, Wu X*
Sci Rep. 2017 Apr 4;7:45401.
2017 03/01

PKA-RIIB deficiency induces brown fat-like adipocytes in inguinal WAT and promotes energy expenditure in male FVB/NJ mice.

Jing S, Wu W, Huang S, Xue R, Wang Y, Wan Y, Zhang L, Qin L, Zhang Q, Zhu X, Zhang Z, Ye H, Wu X, Li Y
Endocrinology. 2017 Mar 1;158(3):578-591.
2017 02/16

郑煜芳课题组与苏州大学孙淼、徐兴顺课题组合作发现 Zfp462 缺失导致小鼠焦虑症

郑煜芳课题组与苏州大学孙淼、徐兴顺课题组合作，从 PiggyBac 转座子随机插入获得突变小鼠库中，筛查获得纯合敲除导致胚胎期死亡的 Zfp462 基因。
2017 02/01

ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons.

Yang Z, Li PF, Chen RC, Wang J, Wang S, Shen Y, Wu X, Fang B, Cheng X, Xiong ZQ
Cereb Cortex. 2017 Feb 1;27(2):919-932.
2017 02/01

Dendritic cell Mst1 inhibits Th17 differentiation.

Li C., Bi Y., Li Y.,Yang H., Yu Q., Wang J., Wang Y., Su H., Jia A., Hu1 Y., Han1 L., Zhang J., Simin Li S., Tao W. & G Liu
Nat. Comm. 2017 Feb 1;8:14275.
2016 10/18

郑煜芳课题组鉴定 PCP 通路核心成员 CELSR1-3 在先心病和神经管畸形中的突变

先天性心脏病（CHD）和神经管畸形（NTD）是两种发病率最高的导致器官畸形的出生缺陷，对于其遗传机制的理解有助于推广产前检测筛查，提高人口素质，减低家庭和社会负担。
2016 10/01

Gen1 and Eme1 play redundant roles in DNA repair and meiotic recombination in mice.

Wang X, Wang H, Guo B, Zhang Y, Gong Y, Zhang C, Xu H, Wu X
DNA Cell Bio. 2016 OCT; 35(10): 585-590. doi: 10.1089/dna.2015.3022.

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