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2017 06/06

Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

Zhu X, Xie S, Xu T, Wu X*, Han M
Mol Metab. 2017 Jun; 6: 494-502.
2017 04/17

Large is required for normal astrocyte migration and retinal vasculature development.

Zhou M, Wang H, Ren H, Jiang R, Zhang C, Wu X*, Xu G*
Cell Biosci. 2017 Apr 17;7:18.
2017 04/15

L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration.

Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan KL
Mol Cell Biol. 2017 Apr 15;37(8):e00492-16.
2017 04/04

The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice.

Li G, Ye ZS, Shi C, Sun L, Han M, Zhuang Y, Xu T, Zhao SM, Wu X*
Sci Rep. 2017 Apr 4;7:45401.
2017 03/01

PKA-RIIB deficiency induces brown fat-like adipocytes in inguinal WAT and promotes energy expenditure in male FVB/NJ mice.

Jing S, Wu W, Huang S, Xue R, Wang Y, Wan Y, Zhang L, Qin L, Zhang Q, Zhu X, Zhang Z, Ye H, Wu X, Li Y
Endocrinology. 2017 Mar 1;158(3):578-591.
2017 02/16

郑煜芳课题组与苏州大学孙淼、徐兴顺课题组合作发现 Zfp462 缺失导致小鼠焦虑症

郑煜芳课题组与苏州大学孙淼、徐兴顺课题组合作，从 PiggyBac 转座子随机插入获得突变小鼠库中，筛查获得纯合敲除导致胚胎期死亡的 Zfp462 基因。
2017 02/01

ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons.

Yang Z, Li PF, Chen RC, Wang J, Wang S, Shen Y, Wu X, Fang B, Cheng X, Xiong ZQ
Cereb Cortex. 2017 Feb 1;27(2):919-932.
2017 02/01

Dendritic cell Mst1 inhibits Th17 differentiation.

Li C., Bi Y., Li Y.,Yang H., Yu Q., Wang J., Wang Y., Su H., Jia A., Hu1 Y., Han1 L., Zhang J., Simin Li S., Tao W. & G Liu
Nat. Comm. 2017 Feb 1;8:14275.
2016 10/18

郑煜芳课题组鉴定 PCP 通路核心成员 CELSR1-3 在先心病和神经管畸形中的突变

先天性心脏病（CHD）和神经管畸形（NTD）是两种发病率最高的导致器官畸形的出生缺陷，对于其遗传机制的理解有助于推广产前检测筛查，提高人口素质，减低家庭和社会负担。
2016 10/01

Gen1 and Eme1 play redundant roles in DNA repair and meiotic recombination in mice.

Wang X, Wang H, Guo B, Zhang Y, Gong Y, Zhang C, Xu H, Wu X
DNA Cell Bio. 2016 OCT; 35(10): 585-590. doi: 10.1089/dna.2015.3022.
2016 08/08

吴晓晖教授课题组发现 GPR45 调控能量代谢与肥胖

吴晓晖教授课题组利用piggyBac转座子插入突变小鼠资源发现了G蛋白偶联受体GPR45在肥胖发生发展中的重要作用，阐明了GPR45调控阿黑皮素原(POMC)表达及机体能量代谢的分子机制。
2016 07/26

New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon.

Liu J, Sun L, Shen Q, Wu X, Xu H
BMC Nephrol. 2016 Jul 26;17(1):98.
2016 07/18

Analysis of PBase Binding Profile Indicates an InsertionTarget Selection Mechanism Dependent on TTAA, ButNot Transcriptional Activity.

Dong Yang, Ruiqi Liao, Yun Zheng, Ling Sun, Tian Xu
Int. J. Biol. Sci. 2016; 12(9): 1074-1082. doi: 10.7150/ijbs.15589.
2016 07/01

Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury.

Siqi Zhao, Jie Yin, Lujun Zhou, Feng Yan, Qing He, Li Huang, Shengyi Peng, Junying Jia, Jinbo Cheng, Hong Chen, Wufan Tao, Xunming Ji, Yun Xu, Zengqiang Yuan
Brain Behavior and Immunity. 2016 Jul;5:236-248 SI. doi: 10.1016/j.bbi.2015.12.016.
2016 06/10

Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice.

Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han, Xiaohui Wu
Cell Biosci. 2016 Jun 10;6:41. doi: 10.1186/s13578-016-0108-4.
2016 06/07

Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy.

Zhisheng Ye, Lei Sun, Rongbo Li, Min Han, Yuan Zhuang, Xiaohui Wu, Tian Xu
Int. J. Biol. Sci. 2016; 12(8): 911-916. doi:10.7150/ijbs.15172.
2016 06/04

Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy.

Shuang Li, Kaiqi Mo, Hong Tian, Chen Chu, Shuna Sun, Lei Tian, Sheng Ding, Tong-ruei Li, Xiaohui Wu, Fang Liu, Zhen Zhang, Tian Xu,Ling V. Sun
Cell Biosci. 2016 Jun 4;6:38. doi: 10.1186/s13578-016-0101-y.
2016 05/18

Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

Geng C, Zhang YL, Gao Y, Tao WF, Zhang HB, Liu XJ, Fang FD, Chang YS
Biochemical and Biophysical Research Communications. 2016 Mar 18;471(4):444-449. doi: 10.1016/j.bbrc.2016.02.059.
2016 04/28

Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining.

Yan Liu, Tong-Ruei R Li, Cong Xu, Tian Xu
Int J Biol Sci. 2016 Apr 28;12(6):701-9. doi: 10.7150/ijbs.13635.

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