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2016 08/08

吴晓晖教授课题组发现 GPR45 调控能量代谢与肥胖

吴晓晖教授课题组利用piggyBac转座子插入突变小鼠资源发现了G蛋白偶联受体GPR45在肥胖发生发展中的重要作用，阐明了GPR45调控阿黑皮素原(POMC)表达及机体能量代谢的分子机制。
2016 07/26

New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon.

Liu J, Sun L, Shen Q, Wu X, Xu H
BMC Nephrol. 2016 Jul 26;17(1):98.
2016 07/18

Analysis of PBase Binding Profile Indicates an InsertionTarget Selection Mechanism Dependent on TTAA, ButNot Transcriptional Activity.

Dong Yang, Ruiqi Liao, Yun Zheng, Ling Sun, Tian Xu
Int. J. Biol. Sci. 2016; 12(9): 1074-1082. doi: 10.7150/ijbs.15589.
2016 07/01

Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury.

Siqi Zhao, Jie Yin, Lujun Zhou, Feng Yan, Qing He, Li Huang, Shengyi Peng, Junying Jia, Jinbo Cheng, Hong Chen, Wufan Tao, Xunming Ji, Yun Xu, Zengqiang Yuan
Brain Behavior and Immunity. 2016 Jul;5:236-248 SI. doi: 10.1016/j.bbi.2015.12.016.
2016 06/10

Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice.

Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han, Xiaohui Wu
Cell Biosci. 2016 Jun 10;6:41. doi: 10.1186/s13578-016-0108-4.
2016 06/07

Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy.

Zhisheng Ye, Lei Sun, Rongbo Li, Min Han, Yuan Zhuang, Xiaohui Wu, Tian Xu
Int. J. Biol. Sci. 2016; 12(8): 911-916. doi:10.7150/ijbs.15172.
2016 06/04

Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy.

Shuang Li, Kaiqi Mo, Hong Tian, Chen Chu, Shuna Sun, Lei Tian, Sheng Ding, Tong-ruei Li, Xiaohui Wu, Fang Liu, Zhen Zhang, Tian Xu,Ling V. Sun
Cell Biosci. 2016 Jun 4;6:38. doi: 10.1186/s13578-016-0101-y.
2016 05/18

Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

Geng C, Zhang YL, Gao Y, Tao WF, Zhang HB, Liu XJ, Fang FD, Chang YS
Biochemical and Biophysical Research Communications. 2016 Mar 18;471(4):444-449. doi: 10.1016/j.bbrc.2016.02.059.
2016 04/28

Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining.

Yan Liu, Tong-Ruei R Li, Cong Xu, Tian Xu
Int J Biol Sci. 2016 Apr 28;12(6):701-9. doi: 10.7150/ijbs.13635.
2016 04/01

Mild decrease in TBX20 promoter activity is a potentially protective factor against congenital heart defects in the Han Chinese population.

Yu LW, Wang F, Yang XY, Sun SN, Zheng YF, Li BB, Gui YH, Wang HY
Scientific Reports. 2016 Apr 1;6:23662. doi: 10.1038/srep23662.
2016 03/18

MST1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. Biochem Biophys Res Commun.

Geng C., Zhang Y., Gao Y., Tao W., Zhang H., Liu X., Fang F.. and Y. Chang
(2016) Biochem Biophys Res Commun. 471:444-9.
2016 02/12

MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.

Bin Liu, Anyun Ma, Feng Zhang, Yumeng Wang, Zengmin Li, Qingyu Li, Zhiheng Xu and Yufang Zheng
Scientific Reports. 2016 Feb 12; 6:21534. doi: 10.1038/srep21534.
2015 12/25

Mammalian sterile 20-like kinase 1 (Mst1) enhances the stability of forkhead box P3 (Foxp3) and the function of regulatory T cells by modulating Foxp3 acetylation.

Li C, Shi H, Du X, Deng K, Chi H, Tao W
Journal Of Biological Chemistry 2015 290(52): 30762-770.
2015 11/19

NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance.

Li F, He X, Ye D, Lin Y, Yu H, Yao C, Huang L, Zhang J, Wang F, Xu S, Wu X, Liu L, Yang C, Shi J, He X, Liu J, Qu Y, Guo F, Zhao J, Xu W, Zhao S
Mol Cell. 2015 Nov 19;60(4):661-75. Epub 2015 Nov 19.
2015 06/04

The non-canonical Hippo/Mst pathway in lymphocyte development and functions.

Du X, Yu A, Tao W
2015 47(1): 60-64.
2015 06/01

Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy.

Lei Tian, Sheng Ding Yun You Tong-ruei Li Yan Liu, Xiaohui Wu, Ling Sun and Tian Xu
Disease Models & Mechanisms. 2015 Jun 1; 8(6): 635–641. doi: 10.1242/dmm.019430.
2015 03/10

PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.

Ye, J., Shi, H., Shen, Y., Li, C., Peng, C., Liu, Y., Deng, K., Geng, JG, Xu, T., Zhuang, Y., Zheng, B and W. Tao
Dev Biol. 2014 Aug 1;392(1):108-16. doi: 10.1016/j. ydbio.2014.04.018. Epub 2014 May 4.
2014 08/10

Phosphorylation of CDK2 at threonine 160 regulates meiotic p achytene and diplotene progression in mice.

Liu W, Wang L, Zhao W, Song G, Xu R, Wang G, Wang F, Li W, Lian J, Tian H, Wang X, Sun F.
Nat Immunol. 2014 Jul;15(7):612-22. do i: 10.1038/ni.2898. Epub 2014 May 25.
2014 07/20

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.

Liu J, Han C, Xie B, Wu Y, Liu S, Chen K, Xia M, Zhang Y, Song L, Li Z, Zhang T, Ma F, Wang Q, Wang J, Deng K, Zhuang Y, Wu X, Yu Y, Xu T, Cao X.
Hum Mol Genet. 2014 Jul 15;23(14):3792-800. do i: 10.1093/hmg/ddu092. Epub 2014 Feb 23.

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