1976年5月出生，研究员、博导。1993年进入清华大学生物科学与技术系，1997年获学士学位，1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系，于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship，从事博士后研究。2007年起获聘为复旦大学副教授。2013年8月兼职复旦大学发育生物学研究所PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副研究员PI，2017年12月起任研究员。曾获得上海市浦江人才计划，复旦大学卓学人才计划等奖项。承担的多项国家自然基金委项目和上海市科委项目；并作为课题骨干参与国家重点研发计划、973计划、863等多项重大项目。入职以来共发表论文50余篇，其中在Cell Research, Cell Death & Differentiation, Cell Death & Disease, Cell Discovery, Clinical Science等杂志上发表第一作者和通讯作者论文近三十篇。

利用遗传、发育、分子、生化、动物模型、类器官模型等多种手段研究早期胚胎发育异常导致的神经系统重大疾病的分子遗传和发育机制。

2015年  复旦大学 三八红旗手

2012-2014年  复旦大学卓学计划

2010,2012-2014年  复星医药奖教金“个人奖”四次

2008年 上海市浦江人才计划，2010年结题获评优秀

1.Zhao Ying#, Chen Duoyuan#, Tang Jianping, Zheng Y*, Qi Ji*, Wang H*. Parental folate deficiency induces birth defects in mice accompanied with increased de novo mutations. Cell Discov. 2022 Feb 22; 8(1):18. DOI: 10.1038/s41421-021-00364-0. PMID: 35190523. WOS:000758866600002

2.Yan L, Zheng Y*. Cilia and their role in neural tube development and defects. Reprod Dev Med. 2022 June; 6(2):67-78 DOI: 10.1097/RD9.0000000000000014. WOS:000816750200002

3.Wang Y, Wu Y, Zheng Y*, Wang H*. MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα. Cell Death & Dis. 2021 Oct 25; 12(11):999. DOI: 10.1038/s41419-021-04277-4. PMID: 34697294. WOS: 000710999300003

4.Wu Y, Peng S, Zheng Y*. Organoids as a new model system to study neural tube defects. FASEB J. 2021 Apr; 35(4):e21545. DOI: 10.1096/fj.202002348R. WOS: 000635216100059

5.Li C, Zheng Y, Zheng Y*, Xu Z*. SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development. Cell Death & Dis. 2021 Jan 12; 12(1):75. DOI: 10.1038/s41419-020-03363-3. PMID: 33436552. WOS:000610038300006

6.Xu Y, Li X, Zhong Y, Zheng Y*. Evolution and diversity of axon guidance Robo receptor family genes. J Syst Evol. 2021, 59 (1): 169-182, DOI: 10.1111/jse.12587, WOS:000529752000001

7.Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y*. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. J Hum Genet. 2020 Nov; 65(11):985-993. DOI: 10.1038/s10038-020-0793-z. WOS:000542531800001

8.Shi Z, Chen S, Han X, Peng R, Luo J, Yang L, Zheng Y*, Wang H*. The rare mutation in the endosome-associated recycling protein gene VPS50 is associated with human neural tube defects. Mol Cytogenet. 2019 Feb; 12: 8, DOI: 10.1186/s13039-019-0421-9. PMCID: PMC6381738, WOS:000459438700001

9.Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 22;133(2):225-238. DOI: 10.1042/CS20180842. PMID: 30610007, WOS:000461202100005

10.Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ. 2019 Oct;26(10):1863-1879. DOI: 10.1038/s41418-018-0257-6 PMID: 30560934, WOS:000485780700001

11.Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Oct;28(10):1039-1041. DOI: 10.1038/s41422-018-0061-3. Epub 2018 Jul 5. PMID: 29976953, WOS:000446172500010

12.Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death & Dis. 2018 May 1; 9(520). DOI: 10.1038/s41419-018-0563-4 PMID: 29725084, WOS:000431788100015

13.Gao X, Finnell R, Wang H, Zheng Y*. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res 2018 Jul 17;110(12):982-993. DOI: 10.1002/bdr2.1336. Epub 2018 May 6. PMID: 29732722, WOS:000445630800003

14.Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res 2018 Jan 15;110(1):63-71. DOI: 10.1002/bdr2.1122. PMID: 28960852, WOS:000419772900008

15.Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017 Feb;16(2):296-307. DOI: 10.1111/gbb.12339. PMCID: PMC5938703, WOS:000397021100008

16.Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 1; 130(24): 2329-40. DOI: 10.1042/CS20160686. PMID: 27756857, WOS:000393771600010

17.Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Scientific reports 2016 Feb 12;6:21534. DOI: 10.1038/srep21534. PMID: 26867947, WOS:000369933800001

18.Li Q, Liu B, Zhang Z, Zhou M, Pan L, Ma Z, Li Z, Zheng Y*. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. PLoS ONE 2013 Jun; 8(6): e65703. PMID: 23755270, WOS:000319872300091

19.Ma Z, Li Q, Zhang Z, Zheng Y*. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res. 2013 Jan 5, 8(1):24-30. PMID: 25206368, WOS:000314793500004

20.Li J, Liu B, Gao X, Ma Z, CaoSong T, Mei Y, Zheng Y*. Overexpression of Sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro. Protein Cell 2012 Feb; 3(2): 153-9. PMID: 22322890, WOS:000310526200012

21.Zhang WB, Cheng MJ, Huang YT, Jiang W, Cong Q, Zheng YF*, Xu CJ*. A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice. Eur J Obstet Gynecol Reprod Biol. 2012 Feb; 160(2): 185-90. PMID: 22118886, WOS:000300860600013

22.Zhang LP#, Zheng Y#, Li D*, Zhong Y*. Self-organizing Map of Gene Regulatory Networks for Cell Phenotypes during Reprogramming. Comput Biol Chem 2011 Aug 10; 35(4):211-7. PMID: 21864790, WOS:000295242500001

23.Jin K, Xue C, Qian J, Zhu Y, Wu X, Yang Z, Yonezawa T, M. James C. Crabbe, Cao Y, Hasegawa M, Zhong Y*, Zheng Y*. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS ONE 2011 Jul 27;6(7):e22602. PMID: 21818345, WOS:000293282700046

24.Kang Y, Zhang X, Jiang W, Wu C, Chen C, Gu J, Zheng Y*, and Xu C* The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT. Cell Biol Int. 2009 Apr; 33(4): 509-515. PMID: 19353779, WOS:000264813500007

25.Zheng Y, Peschon J, Saftig P, Hartmann D, Blobel CP. Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17). J. Biol Chem. 2004 Oct 8; 279(41): 42898-906 PMID: 15292243, WOS:000224226400068

26.Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 8; 277(45): 42463-70PMID: 12207026, WOS:000179081200007

27.鲁月，罗婧，颜璐，吴宇，郑煜芳*。RNA内切酶CPSF3受E3泛素化连接酶UBE3D调控。复旦学报（自然科学版）, 2022 Jan; 61(1):43-51

28.罗婧，杨丝雨，吴宇，王雨萌，郑煜芳*。miR-197结合HNRNPD的5’UTR区上调其蛋白表达。复旦学报（自然科学版）, 2021 Jan; 60(1):47-57

29.周梅，李增民，郑煜芳*。ALS相关突变型σ1R的激活促进大鼠施旺细胞RSC96的凋亡。复旦学报（自然科学版）, 2017 Dec; 56(6):689-697

30.景迎春，李擎瑜，刘彬，郑煜芳*。HB-EGF可挽救ADAM17缺失导致的大脑皮层神经前体细胞分化迁移异常。复旦学报（自然科学版）, 2017 Oct; 56(5):602-609

31.刘丽萍，曹宋天祎，王劲桁，刘彬，郑煜芳*。脂多糖促进的小鼠原代星形胶质细胞中TGF的释放不依赖与ADAM17的剪切作用。复旦学报（自然科学版）, 2013 Dec; 52(6):731

32.潘乐，马执行，李擎瑜，刘彬，盖敏，郑煜芳*。小鼠大脑皮层中ADAM17表达的降低对神经元前体细胞外向迁移的抑制作用。复旦学报（自然科学版）, 2011 Oct; 50(5):597-604