1976年5月出生，研究员、博导。1993年进入清华大学生物科学与技术系，1997年获学士学位，1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系，于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship，从事博士后研究。2007年起获聘为复旦大学副教授。2013年8月兼职复旦大学发育生物学研究所PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副研究员PI，2017年12月起任研究员。曾获得上海市浦江人才计划，复旦大学卓学人才计划等奖项。承担的多项国家自然基金委项目和上海市科委项目；并作为课题骨干参与国家重点研发计划、973计划、863等多项重大项目。入职以来共发表论文50余篇，其中在Cell Research, Cell Death & Differentiation, Cell Death & Disease, Cell Discovery, Clinical Science等杂志上发表第一作者和通讯作者论文近三十篇。

利用遗传、发育、分子、生化、动物模型、类器官模型等多种手段研究早期胚胎发育异常导致的神经系统重大疾病的分子遗传和发育机制。

2015年  复旦大学 三八红旗手

2012-2014年  复旦大学卓学计划

2010,2012-2014年  复星医药奖教金“个人奖”四次

2008年 上海市浦江人才计划，2010年结题获评优秀

1.Mi Y, Yan L, Wu Y, Zheng Y*. Deficiency of UBE3D in mice leads to severe embryonic abnormalities and disrupts the mRNA of Homeobox genes via CPSF3.  Cell Death Discov. 2025 Mar 12; 11(99). DOI: 10.1038/s41420-025-02387-y

2.Wu Y, Wang Y, Dong Y, Sun V. L, Zheng Y*. Lactate promotes H3K18 lactylation in human neuroectoderm differentiation. Cell. Mol. Life Sci. 2024 Nov 20;81(1):459. DOI: 10.1007/s00018-024-05510-x.

3.Yan L, Yin H, Mi Y, Wu Y, Zheng Y*. Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Front. Cell Dev. Biol. 2023 May 9. 11:1084245. DOI: 10.3389/fcell.2023.1084245.

4.Peng S, Wu Y, Zheng Y*. High glucose causes developmental abnormalities in neuroepithelial cysts with actin and HK1 distribution changes. Front. Cell Dev. Biol. 2023 Jan 6.10:1021284. DOI: 10.3389/fcell.2022.1021284.

5.Zhao Y#, Chen D#, Tang J, Zheng Y*, Qi Ji*, Wang H*. Parental folate deficiency induces birth defects in mice accompanied with increased de novo mutations. Cell Discov. 2022 Feb 22; 8(1):18. DOI: 10.1038/s41421-021-00364-0. PMID: 35190523.

6.Wang Y, Wu Y, Zheng Y*, Wang H*. MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα. Cell Death & Dis. 2021 Oct 25; 12(11):999. DOI: 10.1038/s41419-021-04277-4. PMID: 34697294.

7.Wu Y, Peng S, Zheng Y*. Organoids as a new model system to study neural tube defects. FASEB J. 2021 Apr; 35(4): e21545. DOI: 10.1096/fj.202002348R.

8.Li C, Zheng Y, Zheng Y*, Xu Z*. SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development. Cell Death & Dis. 2021 Jan 12; 12(1):75. DOI: 10.1038/s41419-020-03363-3. PMID: 33436552

9.Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y*. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. J Hum Genet. 2020 Nov; 65(11):985-993. DOI: 10.1038/s10038-020-0793-z.

10.Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 22;133(2):225-238. DOI: 10.1042/CS20180842. PMID: 30610007

11.Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ. 2019 Oct;26(10):1863-1879. DOI: 10.1038/s41418-018-0257-6 PMID: 30560934

12.Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Oct;28(10):1039-1041. DOI: 10.1038/s41422-018-0061-3. Epub 2018 Jul 5. PMID: 29976953

13.Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death & Dis. 2018 May 1; 9(520). DOI: 10.1038/s41419-018-0563-4 PMID: 29725084

14.Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017 Feb;16(2):296-307. DOI: 10.1111/gbb.12339. PMCID: PMC5938703

15.Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 1; 130(24): 2329-40. DOI: 10.1042/CS20160686. PMID: 27756857