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郑煜芳 博士

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    1993年进入清华大学生物科学与技术系,1997年获学士学位,1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系,于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship,从事博士后研究。2007年起获聘为复旦大学副教授,硕导。2013年8月兼职复旦大学发育生物学研究所PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副研究员PI,2017年12月起任研究员。曾获得上海市浦江人才计划,复旦大学卓学人才计划等奖项。曾承担的多项国家自然基金委项目和上海市科委项目;作为课题骨干参与基金委重点项目、国家重点研发计划、973计划、863等多项重大项目。

     

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    实验室的研究方向研究胚胎发育异常导致的重大疾病的分子遗传和发育机制,包括:1)大脑神经干细胞发育及发育障碍相关疾病;2)神经管畸形和先心病的遗传分子和病理机制;3)崎胎瘤等生殖细胞肿瘤的遗传和分子病理机制。

     

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    2015年  复旦大学 三八红旗手

    2012-2014年  复旦大学卓学计划

    2010,2012-2014年  复星医药奖教金“个人奖”四次

    2008年 上海市浦江人才计划,2010年结题获评优秀

     

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    1.Xu Y, Li X, Zhong Y, Zheng Y*. The evolution and diversity of axon guidance Robo receptor family genes. Journal of Systematics and Evolution, 2020 April 10th, https://doi.org/10.1111/jse.12587

    2.Shi Z, Chen S, Han X, Peng R, Luo J, Yang L, Zheng Y*, Wang H*. The rare mutation in the endosome-associated recycling protein gene VPS50 is associated with human neural tube defects. Mol Cytogenet. 2019 Feb; 12: 8, doi: 10.1186/s13039-019-0421-9. PMCID: PMC6381738

    3.Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 31;133(2):225-238. doi: 10.1042/CS20180842. PMID: 30610007

    4.Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ 2019 Oct;26(10):1863-1879. DOI: 10.1038/s41418-018-0257-6 PMID: 30560934

    5.Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Oct;28(10):1039-1041. doi: 10.1038/s41422-018-0061-3. Epub 2018 Jul 5. PMID: 29976953

    6.Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death & Dis. 2018 May 1; 9(520). doi: 10.1038/s41419-018-0563-4 PMID: 29725084

    7.Gao X, Finnell R, Wang H, Zheng Y*. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res 2018 Jul 17;110(12):982-993. doi: 10.1002/bdr2.1336. Epub 2018 May 6. PMID: 29732722

    8.Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res 2018 Jan 15;110(1):63-71. doi: 10.1002/bdr2.1122. PMID: 28960852

    9.Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017 Feb;16(2):296-307. PMCID: PMC5938703

    10.Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 1; 130(24): 2329-40. PMID: 27756857

    11.Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Scientific reports 2016 Feb 12;6:21534. doi: 10.1038/srep21534. PMID: 26867947

    12.Li Q, Liu B, Zhang Z, Zhou M, Pan L, Ma Z, Li Z, Zheng Y*. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. PLoS ONE 2013 Jun; 8(6): e65703. PMID: 23755270

    13.Ma Z, Li Q, Zhang Z, Zheng Y*. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res. 2013 Jan 5, 8(1):24-30. PMID: 25206368

    14.Li J, Liu B, Gao X, Ma Z, CaoSong T, Mei Y, Zheng Y*. Overexpression of Sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro. Protein Cell 2012 Feb; 3(2): 153-9. PMID: 22322890

    15.Zhang WB, Cheng MJ, Huang YT, Jiang W, Cong Q, Zheng YF*, Xu CJ*. A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice. Eur J Obstet Gynecol Reprod Biol. 2012 Feb; 160(2): 185-90. PMID: 22118886

    16.Zhang LP#, Zheng Y#, Li D, Zhong Y. Self-organizing Map of Gene Regulatory Networks for Cell Phenotypes during Reprogramming. Comput Biol Chem 2011 Aug 10; 35(4):211-7. PMID: 21864790

    17.Jin K, Xue C, Qian J, Zhu Y, Wu X, Yang Z, Yonezawa T, M. James C. Crabbe, Cao Y, Hasegawa M, Zhong Y*, Zheng Y*. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS ONE 2011 Jul 27;6(7):e22602. PMID: 21818345

    18.Kang Y, Zhang X, Jiang W, Wu C, Chen C, Gu J, Zheng Y*, and Xu C* The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT. Cell Biol Int. 2009 Apr; 33(4): 509-515. PMID: 19353779

    19.Zheng Y, Peschon J, Saftig P, Hartmann D, Blobel CP. Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17). J. Biol Chem. 2004 Oct 8; 279(41): 42898-906 PMID: 15292243

    20.Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 8; 277(45): 42463-70  PMID: 12207026

    21.罗婧,杨丝雨,吴宇,王雨萌,郑煜芳*。miR-197结合HNRNPD的5’UTR区上调其蛋白表达。复旦学报(自然科学版), 2020

    22.周梅,郑煜芳*。ALS相关突变型σ1R的激活促进大鼠施旺细胞RSC96的凋亡。复旦学报(自然科学版), 2017 Dec; 56(6):689-69723.景迎春,李擎瑜,刘彬,郑煜芳*。HB-EGF可挽救ADAM17缺失导致的大脑皮层神经前体细胞分化迁移异常。复旦学报(自然科学版), 2017 Oct; 56(5):602-609

    24.刘丽萍,曹宋天祎,王劲桁,刘彬,郑煜芳*。脂多糖促进的小鼠原代星形胶质细胞中TGF的释放不依赖与ADAM17的剪切作用。复旦学报(自然科学版), 2013 Dec; 52(6):731

    25.潘乐,马执行,李擎瑜,刘彬,盖敏,郑煜芳*。小鼠大脑皮层中ADAM17表达的降低对神经元前体细胞外向迁移的抑制作用。复旦学报(自然科学版), 2011 Oct; 50(5):597-604