MORE研究所科研动态

2023 05/18

An miRNA-mRNA integrative analysis in human placentas and mice: role of the Smad2/miR-155-5p axis in the development of fetal growth restriction
Functional disorder of the placenta is the principal cause of fetal growth restriction (FGR), usually cured with suitable clinical treatment and good nursing. However, some FGR mothers still give birth to small for gestational age (SGA) babies after treatment. The ineffectiveness of treatment in such a group of patients confused physicians of obstetrics and gynecology.【详细】
2022 02/22

Parental folate deficiency induces birth defects in mice accompanied with increased de novo mutations
Whole-genome sequencing of multiple sibship with F1 males on the FD diet showed that the de novo mutation (DNM) rate in F2 embryos was three times of the reported spontaneous rate in mice. Furthermore, many DNMs observed in the F2 mice exhibited an allele ratio of 1:3 instead of 2:2, suggesting that these mutations are likely to accumulate in gamete cells as a form of mismatch in the DNA duplex. 【详细】
2022 01/22

Disruption of Gen1 Causes Ectopic Budding and Kidney Hypoplasia in Mice
Congenital anomalies of the kidney and urinary tract (CAKUT) are a family of often-concurrent diseaseswith various anatomical spectra. Null-mutantGen1mice frequently develop multiple urinary pheno-types, most commonly...【详细】
2022 01/21

Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila
The secreted ATP possibly feeds back to kill ISCs by activating inflammasome-like pyroptosis. We identify an evolutionarily conserved pathway that sustains stem cells and CSCs, and its ablation results in an immunogenic cascade that promotes death of stem cells and CSCs as well as antitumor immunity.【详细】
2022 01/06

Cilia and their role in neural tube development and defects
Recent studies have highlighted the association of phosphoinositide signaling with cilia, thereby conferring novel insights into the function of cilia during neural tube development. Here, we have reviewed recent studies on cilia, focusing on the molecular mechanism underlying the involvement of cilia in neural tube development and the role of ciliary disruption in the development of NTDs.【详细】