1998年进入复旦大学生命科学学院，2002年获学士学位。2002年-2008年就读于复旦大学发育生物学研究所，获得博士学位。2008-2011年在美国斯克利普斯研究所（The Scripps Research Institute）从事博士后研究。2011-2017年担任德克萨斯大学西南医学中心（University of Texas Southwestern Medical Center at Dallas）讲师（Instructor）。2017-2019年作为联合创始人和首席技术官（Chief Technology Officer）筹建和负责上海近岸生物科技有限公司（CytoCares）的新药研发，并作为课题负责人获得科技部国家重大新药创制专项基金支持。2019年被复旦大学发育生物学研究所聘为青年研究员。2020年起兼任复旦大学附属中山医院肿瘤内科双聘PI。

▪创新型免疫治疗药物和机理研究及临床应用，包括自然杀伤（NK）细胞和肿瘤浸润淋巴细胞（TIL）等细胞药物开发

▪新型抗体和 TCR 筛选平台构建，该平台将依赖于微流控和单细胞测序，高效快速地从病人体内分离肿瘤特异性 B 细胞和肿瘤浸润淋巴细胞（TIL），通过进一步改造扩增转化为新型治疗手段

▪研究不同生理反应对于免疫调控的不同影响，本工作将基于 Mutagenetix 项目中得到的小鼠模型，其中包括涉及细胞凋亡和代谢等领域对于免疫调控的影响，相关研究为全新未知领域

▪疾病动物模型构建，应用于快速诊断和药物开发

1.HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. Lei Sun, Zhengfan Jiang, Victoria A. Acosta-Rodriguez, Michael Berger, Xin Du, Jin Huk Choi, Jianhui Wang, Kuan-wen Wang, Gokhul K. Kilaru, Jennifer A. Mohawk, Jiexia Quan, Lindsay Scott, Sara Hildebrand, Xiaohong Li, Miao Tang, Xiaoming Zhan, Anne R. Murray, Diantha La Vine, Eva Marie Y. Moresco, Joseph S. Takahashi, Bruce Beutler. J Exp Med., 2017 Nov 2;214(11):3263-3277.

2.Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. Sun L*, Ye Z*, Li R*, Han M, Zhuang Y, Wu X, Xu T. Int J Biol Sci., 2016 Jun 7;12(8):911-6.

3.MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Lei Sun*, Katharina Brandl*, Christina Neppl, Owen M. Siggs, Sylvain M. Le Gall, Wataru Tomisato, Xiaohong Li, Xin Du, Daniela N. Maennel, Carl P. Blobel, Bruce Beutler. PNAS, Vol.107, No. 46, 19967-19972, 2010

4.A Mitotic Recombination System for Mouse Chromosome 17. Lei Sun, Xiaohui Wu, Min Han, Tian Xu, Yuan Zhuang. PNAS, Vol.105, No. 11, 4237-4241, 2008

5.Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B, Turer E. PNAS, 2018 Dec 4;115(49):E11523-E11531. doi: 10.1073/pnas.1814753115. Epub 2018 Nov 15.

6.Real-time resolution of point mutations that cause phenovariance in mice. T. Wang, X. Zhan, C.H. Bu, S. Lyon, D. Pratt, S. Hildebrand, J.H. Choi, Z. Zhang, M. Zeng, K.W. Wang, E. Turer, Z. Chen, D. Zhang, T. Yue, Y. Wang, H. Shi, J. Wang, L. Sun, J. SoRelle, W. McAlpine, N. Hutchins, X. Zhan, M. Fina, R. Gobert, J. Quan, M. Kreutzer, S. Arnett, K. Hawkins, A. Leach, C. Tate, C. Daniel, C. Reyna, L. Prince, S. Davis, J. Purrington, R. Bearden, J. Weatherly, D. White, J. Russell, Q. Sun, M. Tang, X. Li, L. Scott, E.M. Moresco, G.M. McInerney, G.B. Karlsson Hedestam, Y. Xie, B. Beutler. PNAS, Vol. 112, No. 5, 440-449, 2015

7.ENU-induced phenovariance in mice: inferences from 587 mutations. Carrie N Arnold, Michael J Barnes, Michael Berger, Amanda L Blasius, Katharina Brandl, Ben Croker, Karine Crozat, Xin Du, Celine Eidenschenk, Philippe Georgel, Kasper Hoebe, Hua Huang, Zhengfan Jiang, Philippe Krebs, Diantha La Vine, Xiaohong Li, Stephen Lyon, Eva Marie Y Moresco, Anne R Murray, Daniel L Popkin, Sophie Rutschmann, Owen M Siggs, Nora G Smart, Lei Sun, Koichi Tabeta, Wataru Tomisato, Victoria Webster, Sungyong Won, Yu Xia, Nengming Xiao, Bruce Beutler. BMC Res Notes., 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.

8.Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. Won S, Eidenschenk C, Arnold CN, Siggs OM, Sun L, Brandl K, Mullen TM, Nemerow GR, Moresco EM, Beutler B. J Virol, 86:1802-8, (2012)

9.Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B. PNAS, Vol. 108, No. 49, 19678-19682, 2011.

10.Cloning and characterization of a gene encoding phagerelated tail protein (PrTP) of endosymbiont Wolbachia. KANG Lin, SUN Lei, YU Hong, ZHOU Weiguo, ZHAO Shouyuan & LI Changben. Chinese Science Bulletin, Vol.47, No. 17, 1451-1456, 2002

11.Cloning and characterization of a gene encoding glutathione-regulated potassium-efflux system protein KefKL from the endosymbiont Wolbachia. Kang L, Zhu H, Cheng Q, Zhou W, Sun L, Cai L, Ma X, Chen C, Zhao S & Li C. DNA Sequence, Vol.13, No. 6, 375-381, 2002

12.Superinfection of Laodelphax striatellus with Wolbachia from Drosophila simulans. Kang L, Ma X, Cai L, Liao S, Sun L, Zhu H, Chen X, Shen D, Zhao S, Li C. Heredity, Vol.90, No. 1, 71-76, 2003