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郑煜芳 博士

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    1993年进入清华大学生物科学与技术系,1999年获学士学位,1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系,于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship,从事博士后研究。2007年起获聘为复旦大学副教授,硕导。2013年8月复旦大学发育生物学研究所兼职PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副教授PI,2017年12月起任教授,PI。曾获得上海市浦江人才计划,复旦大学卓学人才计划等奖项。近五年承担的重要项目有国家自然基金委面上项目1项和应急管理项目1项,上海市科委重点项目1项;参与基金委重点项目1项,参与973计划课题1项,863课题1项。

     

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    实验室的研究方向为研究胚胎发育异常导致的:1)大脑神经干细胞发育及发育障碍相关疾病;2)神经管畸形和先心病的遗传分子和病理机制。

     

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    2015年 复旦大学 三八红旗手

    2012-2014年 复旦大学卓学计划

    2010,2012-2014年 复星医药奖教金“个人奖”四次

    2008年 上海市浦江人才计划,2010年结题获评优秀

     

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    1. Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 22;133(2):225-238. doi: 10.1042/CS20180842.

    2. Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ 2018 Dec 18th. DOI: 10.1038/s41418-018-0257-6.

    3. Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.,*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Jul 5. doi: 10.1038/s41422-018-0061-3.

    4. Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 3;9(5):520. doi: 10.1038/s41419-018-0563-4.

    5. Gao X, Finnell R, Wang H, Zheng Y*. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res A 2018 May 6. doi: 10.1002/bdr2.1336.

    6. Kim J#, Lei Y#, Guo J, Kim S, Wlodarczyk B, Robert M. Cabrera RM, Lin Y, Nilsson T, Zhang T, Ren A, Wang L, Yuan Z, Zheng Y, Wang H*, Finnell RH.* Formate Rescues Neural Tube Defects Caused by Mutations in Slc25a32. PNAS, 2018 May 1;115(18):4690-4695. doi: 10.1073/pnas.1800138115.

    7. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH*, Zhang T*, Wang H*. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018 Apr 4; 11(1): 38. doi: 10.1186/s12920-018-0355-9.

    8. Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res A 2018 Jan 15;110(1):63-71. doi: 10.1002/bdr2.1122. Epub 2017 Sep 29.

    9. Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations in CELSR1-3 in Chinese Congenital Heart and Neural Tube Defects. Clin Sci (Lond). 2016 Oct 18. 130(24): 2329-40, doi: 10.1042/CS20160686.

    10. Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2016 Sep 13. doi: 10.1111/gbb.12339.

    11. Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Rep, 2016 Feb 12;6:21534. doi: 10.1038/srep21534.

    12. Li P, Li H, Zheng Y, Qiao B, Duan W, Huang L, Liu W, Wang H*. Variants in the Regulatory Region of WNT5A Reduced Risk of Cardiac Conotruncal Malformations in the Chinese Population. Sci Rep, 2015 Aug 17;5:13120.

    13. Li Q, Zhang Z, Li Z, Zhou M, Liu B, Pan L, Ma Z, Zheng Y*. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. PLoS ONE 2013 June 3; 8(6): e65703.

    14. Ma Z, Li Q, Zhang Z, Zheng Y*. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res. 2013 8(1):24-30.

    15. Peng C, Ye J, Yan S, Kong S, Shen Y, Li C, Li Q, Zheng Y, Deng K, Xu T, Tao W. Ablation of vacuole protein sorting 18 (vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21; 287(39):32861-73.

    16. Li J, Liu B, Gao X, Ma Z, CaoSong T, Mei Y, Zheng Y*. Overexpression of Sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro. Protein Cell 2012 Feb; 3(2): 153-9.

    17. Zhang WB, Cheng MJ, Huang YT, Jiang W, Cong Q, Zheng YF*, Xu CJ*. A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice. Eur J Obstet Gynecol Reprod Biol. 2012 Feb; 160(2): 185-90.

    18. Jin K, Xue C, Qian J, Zhu Y, Wu X, Yang Z, Yonezawa T, M. James C. Crabbe, Cao Y, Hasegawa M, Zhong Y*, Zheng Y*. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS ONE 2011; 6(7):e22602.

    19. Zhang LP#, Zheng Y#, Li D, Zhong Y. Self-organizing Map of Gene Regulatory Networks for Cell Phenotypes during Reprogramming. Comput Biol Chem. 2011 Aug 10; 35(4):211-7.

    20. Zhang X, Chen J, Zheng Y, Gao X, Kang Y, Zhang J, Cheng M, Sun H, Xu C* Follicle stimulating hormone peptide can facilitate paclitaxel nanoparticles target to ovarian carcinoma in vivo. Cancer Res 2009 Aug 15; 69(16):6506-14.

    21. Kang Y, Zhang X, Jiang W, Wu C, Chen C, Gu J, Zheng Y*, and Xu C* The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT. Cell Biol Int, 2009 Apr; 33: 509-515.

    22. Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell, 2008 Jun 27; 133: 1241-1254.

    23. Zheng Y, Peschon J, Saftig P, Hartmann D, Blobel CP. Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17). J. Biol Chem. 2004 Oct 8; 279(41): 42898-906.

    24. Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 8; 277(45): 42463-70.