当前位置:首页 / 师资队伍 / PI / 正文

陶无凡 博士

  • 陶无凡 博士

    教授

    遗传工程国家重点实验室PI

    遗传与发育协同创新中心PI

     

    电话: 021-65643718

    E-mail: wufan_tao@fudan.edu.cn

  •  

    1956年出生, 博士,教授。1978-1981年,南京师范大学生物系,获学士学位。1982-1988,复旦大学遗传学研究所,微生物分子遗传,获博士学位。1989-1994年, 美国Memorial Sloan-Kettering癌症中心, 分子发育生物学,博士后。1988-1989年,复旦大学遗传学研究所,讲师。1994-1999年,美国耶鲁大学分子医学中心, Associate Research Scientist。1999-2005年,美国明尼苏达大学 医学系,遗传, 细胞和发育生物,Tenuer-Track-Assistant Professor。2005年起, 复旦大学发育生物学研究所,教授。

     

  •  

    1. 肿瘤抑制基因和转移相关基因在疾病与发育中的功能和分子机制

    2. T细胞发育与自身免疫疾病机理

     

  •  

     

  •  

    1. Li, C., Shi, H., Du, X., Deng, K., Chi, H., and W. Tao (2015) Mammalian sterile 20-like kinase 1 (Mst1) enhances the stability of forkhead box P3 (Foxp3) and the function of regulatory T cells by modulating Foxp3 acetylation. J. Biol. Chem. Online Nov. 3, 2015, DOI 10.1074/jbc.

    2. Ye, J., Shi, H., Shen, Y., Li, C., Peng, C., Liu, Y., Deng, K., Geng, JG, Xu, T., Zhuang, Y., Zheng, B and W. Tao (2015) PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling. J. Immunology 194:1654-1664

    3. Du, X., Yu, A., and W. Tao (2015) The non-canonical Hippo/Mst pathway in lymphocyte development and functions. Acta Biochim Biophys Sin 47, 60–64

    4.Ardestani, A., Paroni, F., Azizivarzaneh, Z., Kaur, S., Khobragade, V., Yuan, T., Frogne, T., Tao, W., Oberholzer J, . J., Pattou, F., Conte, JK. and K. Maedler (2014) MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nature Medicine 20:385-397.

    5. Du, X., Dong, Y., Shi, H., Li, J., Kong, S., Shi, D., Sun, L. V., Deng, K., Xu, T. and W.Tao. (2014) Mst1 and Mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLos One 9(3): e90701

    6. Du, X., Shi, H., Li, J., Dong, Y., Liang, J., Ye, J., Kong, S., Zhang, S., Zhong, T., Yuan, Z., Xu, T., Zhuang, Y., Zheng, B., Geng, J. G. and W. Tao (2014) Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. Journal of Immunology 192 :1525-1535

    7. Kong, S., Du, X., Peng, C., Wu, Y., Li, H., Jin, X., Hou, L., Kejing Deng, K., Xu, T. and W. Tao (2013) Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein. Cell Research 23: 835-850

    8. Peng, C., Ye, J., Yan, S., Shen, Y., Li, C., Li, Q., Zheng, Y., Deng, K., Xu, T. and W. Tao (2012) Vps18 deficiency leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J. Biol. Chem. 287:32861-32873

    9. Peng, C., Yan, S., Ye, J., Shen, L., Xu, T. and W. Tao (2012) Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase. BBRC 423:715-720

    10. Yuan, F., Xie, Y., Wu, J., Bai, Y., Mao, B., Dong, Y., Bi, W., Ji, G., Tao, W., Wang, Y. and Z. Yuan (2011) Mst1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. J. Biol. Chem. 286:6940-6945

    11. Qiao, M., Wang, Y., Xu, X., Lu, J., Dong, Y., Tao, W., Stein, J., Stein, G.S., Iglehart, J.D., Shi, Q., A. B. Pardee (2010) Mst1 Is an Interacting Protein that Mediates PHLPPs’ Induced Apoptosis. Molecular Cell 38: 512-523.

    12. Dong, Y., Du, X., Ye, J., Han, M., Xu, T., Zhuang, Y., W. Tao (2009) A Cell-Intrinsic Role for Mst1 in Regulating Thymocyte Egress. J. Immunology 183:3865-72.

    13. Matsui, Y., Nakano, N., Shao, D., Gao, S,. Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., Tao, W., Wagner, T., Nojima, H., and J. Sadoshima (2008) Lats2 Is a Negative Regulator of Myocyte Size in the Heart. Circulation Research 103(11):1309-18.

    14. Ke, H., Pei, J., Ni, Z., Xia, X., Qi, H., Woods, T., and W. Tao (2004) Putative tumor suppressor LATS2 induces apoptosis through down regulation of Bcl-2 and Bcl-xL. Experimental Cell Research 298: 329-38

    15. Li, Y., Pei, J., Xia, X., Ke, H., Wang, H., and W. Tao (2003) LATS2, a putative tumor suppressor, inhibits G1/S transition. Oncogene, 22: 4398-4405.

    16. Xia, H., Qi,, H., Li, Y., Pei, J., Barton, J., Blackstad, M., Xu, T., and W. Tao (2002) Lats1 regulates G2/M transition and apoptosis. Oncogene 21: 1233-41.

    17. Tao, W., Zhang, S., Stewart, R., St. John, M.A.R. and T. Xu (1999) Human homolog of the Drosophila lats tumor suppressor modulates Cdc2/Cyclin A activity. Nature Genetics 21:177-181.

    18. St. John, M.A.R#, Tao, W #., Fei, X., Fukumoto, R., Carcangiu, M. L., Brownstein, D., Parlow, A. F., Mcgrath, J. and T. Xu, (1999) Mice deficient for lats develop soft tissue sarcoma, ovary tumor and pituitary dysfunction. Nature Genetics 21:182-186. # These two contributed equally.

    19. Huang H., Potter C., Tao W., Li D., Sun H., and T. Xu (1999) PTEN affects cell size, cell proliferation, and apoptosis during Drosophila eye development. Development 126:5362-5372

    20. Turenchalk G.S, St. John M.A.R., Tao W. and T. Xu (1999) The role of lats in cell cycle regulation and tumorigenesis. Biochim. Biophys. Acta 1424(2-3):M9-M16

    21. Li, H., Tao, W. and E. Lai (1996) Characterization of the structure and function of the gene for transcription factors BF-1, an essential regulator of forebrain development. Brain Research. Molecular Brain Research 37:96-104.

    22. Xuan, S., Baptista, C., Balas, G., Tao, W., and E. Lai (1995) Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14:1141-1152.

    23. Hatini, V., Tao, W., and E. Lai (1994) Expression of winged helix gene, BF-1 and BF-2, define adjacent domains within the developing forebrain and retina. Journal of Neurobiology 25:1293-1309.

    24. Clevidence, D. E., Overdier, D. G., Tao, W., Qian, X., Pani, L., Lai, E. and R. H. Costa (1993) Identification of nine novel tissue-specific transcription factors of the HNF-3/fork head DNA binding domain family. Proc. Natl. Acad. Sci. USA 90: 3948-3952.

    25. Tao, W. and E. Lai (1992) Telencephalon restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron 8: 957-966.

    26. Lai, E., Prezioso, V.R., Tao, W., Chen, W.S. and J.E. Darnell (1991) Hepatocyte nuclear factor -3a belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Dev. 5: 416-427.

    27. Yuan, H., Min, Y., Shi, S., Tao, W., Wu, S., Li, Y., Wang, Q., Lu, H., Zhang, C. and Q. Hu (1991) Chemical synthesis, cloning and expression of human epidermal growth factor gene in Sacchromyces cerevisiae Chinese Journal of Biotechnology. 7:253-261.

    28. Sheng, Z. J., Tao, W., Wang, L. L. and R. Q. Shen (1991) Mechanism of Thermoadaption in Thermophilic Bacteria. Prog. in Natural Science., 1:337-341.

    29. Tao, W., Wang, L. L.., Shen, R. Q. and Z. J. Sheng (1989) Complete nucleotide sequences of the two phosphoglucoisomerase isozymes from Bacillus stearothermophilus. Nuc. Acids. Res., 17: 10107-10108.

    30. Tao, W., Shen, R. Q. and Z. J. Sheng (1987) The application of isozyme study on the classification of Bacillus stearothermophilus. Acta Genetica Sinica, 14: 200-205