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孙磊 博士

  • 孙磊 博士

    青年研究员

     

    电话: 021-55665494

    E-mail: lei_sun@fudan.edu.cn

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    1998年进入复旦大学生命科学学院,2002年获学士学位。2002年-2008年就读于复旦大学发育生物学研究所,获得博士学位。2008-2011年在美国斯克利普斯研究所(The Scripps Research Institute)从事博士后研究。2011-2017年担任德克萨斯大学西南医学中心(University of Texas Southwestern Medical Center at Dallas)讲师(Instructor)。2017-2019年作为联合创始人和首席技术官(Chief Technology Officer)筹建和负责上海近岸生物科技有限公司(CytoCares)的新药研发,并作为课题负责人获得科技部国家重大新药创制专项基金支持。2019年被复旦大学发育生物学研究所聘为青年研究员。2020年起兼任复旦大学附属中山医院肿瘤内科双聘PI。

     

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    课题组研究方向为免疫调控及免疫治疗,主要包括:1)抗感染免疫;2)免疫调控机制;3)创新药物和疗法研发。

     

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    1. Sun L, Jiang ZF, Acosta-Rodriguez V, Berger M, Du X, Choi JH, Wang JH, Wang KW, Kilaru G, Mohawk J, Quan JX, Scott L, Hildebrand S, Li XH, Tang M, Zhan XM, Murray A, La Vine D, Moresco EMY, Takahashi J, Beutler B. HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. (2017). J Exp Med. Nov 2;214(11):3263-3277.

    2. Ye Z*, Sun L*, Li R*, Han M, Zhuang Y, Wu X, Xu T. Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. (2016). Int J Biol Sci. Jun 7;12(8):911-6.

    3. Brandl K*, Sun L*, Neppl C, Siggs O, Le Gall S, Tomisato W, Li XH, Du X, Maennel D, Blobel C, Beutler B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. (2010). PNAS. Nov 16; 107(46):19967-19972.

    4. Sun L, Wu XH, Han M, Xu T, Zhuang Y. A Mitotic Recombination System for Mouse Chromosome 17. (2018). PNAS. Mar 18;105(11):4237-4241.

    5. McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B, Turer E. Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. (2018). PNAS. Dec 4;115(49):E11523-E11531.

    6. Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang DW, Yue T, Wang Y, Shi HX, Wang JH, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan JX, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun QH, Tang M, Li XH, Scott L, Moresco EMY, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B. Real-time resolution of point mutations that cause phenovariance in mice. (2015). PNAS. Feb 3;112(5):E440–E449.

    7. Won S, Eidenschenk C, Arnold CN, Siggs OM, Sun L, Brandl K, Mullen TM, Nemerow GR, Moresco EMY, Beutler B. Increased susceptibility to DNA virus infection in mice with a GCN2 mutation. (2012). J Virol. Feb;86(3):1802–1808.

    8. Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EMY, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. (2011). PNAS. Dec 6;108(49):19678–19682.

    9. Kang L, Sun L, YU H, Zhou WG, Zhao SY, LI CB. Cloning and characterization of a gene encoding phagerelated tail protein (PrTP) of endosymbiont Wolbachia. (2002). Chinese Science Bulletin. Sept;47(17):1451-1456.

    10. Kang L, Zhu H, Cheng Q, Zhou W, Sun L, Cai L, Ma X, Chen C, Zhao S, Li CB. Cloning and characterization of a gene encoding glutathione-regulated potassium-efflux system protein KefKL from the endosymbiont Wolbachia. (2002). DNA Sequence. Dec;13(6):375-381.

    11. Kang L, Ma X, Cai L, Liao S, Sun L, Zhu H, Chen X, Shen D, Zhao S, Li CB. Superinfection of Laodelphax striatellus with Wolbachia from Drosophila simulans. (2003). Heredity. Jan 9;90(1):71-76.