• 2018 01/01

    Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice

    Congenital anomalies of the kidney and urinary tract (CAKUT) are among the most common developmental defects in humans...【详细】

  • 2017 11/10

    Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

    Lung cancer is the leading cause of cancer death worldwide. However, the molecular mechanisms underlying lung cancer development have not been fully understood... 【详细】

  • 2017 09/29

    Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects

    Neural tube defects (NTDs), the second most frequent cause of human congenital abnormalities, are debilitating birth defects due to failure of neural tube closure...【详细】

  • 2017 09/19

    Mst-1 deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux

    The mammalian Ste20-like kinase 1 (Mst-1) is a serinethreonine kinase and a component of the Hippo tumor suppressor pathway...【详细】